After studying the 14 matchups on the Week 6 card in the NFL, our best against-the-spread selection is Titans +1. For more suggestions, which could lead to parlay possibilities, scroll down.

NFL Picks Against the Spread – Week 6

Jump to Matchup:

Pick: Titans +1 vs. Colts

• Matchup: Indianapolis Colts at Tennessee Titans
• Projected Winner & Margin: Colts by 0.6 points (Bet on this game at BetMGM)
• Spread: Colts -1
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Bears -2.5 vs. Jaguars

• Matchup: Jacksonville Jaguars vs. Chicago Bears
• Projected Winner & Margin: Bears by 13.5 points (Bet on this game at BetMGM)
• Spread: Bears -2.5
• Time: 9:30 a.m. ET
• Date: Oct. 13
• TV Channel: NFL Network
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Jets +2.5 vs. Bills

• Matchup: Buffalo Bills at New York Jets
• Projected Winner & Margin: Jets by 3.2 points (Bet on this game at BetMGM)
• Spread: Bills -2.5
• Time: 8:15 p.m. ET
• Date: Oct. 14
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Steelers -3 vs. Raiders

• Matchup: Pittsburgh Steelers at Las Vegas Raiders
• Projected Winner & Margin: Steelers by 8.7 points (Bet on this game at BetMGM)
• Spread: Steelers -3
• Time: 4:05 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Broncos +3 vs. Chargers

• Matchup: Los Angeles Chargers at Denver Broncos
• Projected Winner & Margin: Broncos by 6.4 points (Bet on this game at BetMGM)
• Spread: Chargers -3
• Time: 4:05 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Cowboys +3 vs. Lions

• Matchup: Detroit Lions at Dallas Cowboys
• Projected Winner & Margin: Cowboys by 3.1 points (Bet on this game at BetMGM)
• Spread: Lions -3
• Time: 4:25 p.m. ET
• Date: Oct. 13
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Seahawks +3.5 vs. 49ers

• Matchup: San Francisco 49ers at Seattle Seahawks
• Projected Winner & Margin: Seahawks by 1.0 points (Bet on this game at BetMGM)
• Spread: 49ers -3.5
• Time: 8:15 p.m. ET
• Date: Oct. 10
• TV Channel: Amazon Prime Video
• Live Stream: Watch this game on Prime Video (Regional restrictions may apply)

Pick: Saints +3.5 vs. Buccaneers

• Matchup: Tampa Bay Buccaneers at New Orleans Saints
• Projected Winner & Margin: Saints by 0.2 points (Bet on this game at BetMGM)
• Spread: Buccaneers -3.5
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Giants +3.5 vs. Bengals

• Matchup: Cincinnati Bengals at New York Giants
• Projected Winner & Margin: Giants by 5.7 points (Bet on this game at BetMGM)
• Spread: Bengals -3.5
• Time: 8:20 p.m. ET
• Date: Oct. 13
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Packers -5 vs. Cardinals

• Matchup: Arizona Cardinals at Green Bay Packers
• Projected Winner & Margin: Packers by 9.6 points (Bet on this game at BetMGM)
• Spread: Packers -5
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Falcons -6 vs. Panthers

• Matchup: Atlanta Falcons at Carolina Panthers
• Projected Winner & Margin: Falcons by 17.2 points (Bet on this game at BetMGM)
• Spread: Falcons -6
• Time: 4:25 p.m. ET
• Date: Oct. 13
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Commanders +6.5 vs. Ravens

• Matchup: Washington Commanders at Baltimore Ravens
• Projected Winner & Margin: Commanders by 0.4 points (Bet on this game at BetMGM)
• Spread: Ravens -6.5
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Texans -7 vs. Patriots

• Matchup: Houston Texans at New England Patriots
• Projected Winner & Margin: Texans by 11.0 points (Bet on this game at BetMGM)
• Spread: Texans -7
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Eagles -8.5 vs. Browns

• Matchup: Cleveland Browns at Philadelphia Eagles
• Projected Winner & Margin: Eagles by 20.0 points (Bet on this game at BetMGM)
• Spread: Eagles -8.5
• Time: 1:00 p.m. ET
• Date: Oct. 13
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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